In vivo anxiolytic and in vitro anti-inflammatory activities of water-soluble extract (WSE) of Nigella sativa (L.) seeds

The WSE is a highly polar, gummy and mucilaginous bioactive content of the Nigella sativa (L.) seeds. This study reports the anxiolytic and anti-inflammatory effects of WSE investigated using Elevated Plus Maze (EPM) and Hole-Board Test (HBT) in adult mice and human RBCs haemolysis inhibition and pr...

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Main Authors:	Mohammed Babar, Zahir Uddin, Jaswir, Irwandi, Tareq, Abu Montakim, Ali Reza, A. S. M., Wan Sulaiman, Wan Mohd Azizi, Mahamad Maifiah, Mohd Hafidz, Ahfter, F., Hasan, Md Imran, Farhad, Saif, Uddin, Md. Rokib, Ichwan, Solachuddin J. A., Ahmed, Qamar Uddin, Bakhtiar, M. Taher, Mawa, Imranul
Format:	Article
Language:	English English English
Published:	Taylor & Francis Online 2019
Subjects:	QD Chemistry RS403 Materia Medica-Pharmaceutical Chemistry S Agriculture (General)
Online Access:	http://irep.iium.edu.my/75208/ http://irep.iium.edu.my/75208/ http://irep.iium.edu.my/75208/ http://irep.iium.edu.my/75208/1/75208_In%20vivo%20anxiolytic%20and%20in%20vitro.pdf http://irep.iium.edu.my/75208/2/75208_In%20vivo%20anxiolytic%20and%20in%20vitro_SCOPUS%20in%20press.pdf http://irep.iium.edu.my/75208/3/75208_In%20vivo%20anxiolytic%20and%20in%20vitro_WOS%20in%20press.pdf

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spelling	iium-752082020-01-08T08:28:35Z http://irep.iium.edu.my/75208/ In vivo anxiolytic and in vitro anti-inflammatory activities of water-soluble extract (WSE) of Nigella sativa (L.) seeds Mohammed Babar, Zahir Uddin Jaswir, Irwandi Tareq, Abu Montakim Ali Reza, A. S. M. Wan Sulaiman, Wan Mohd Azizi Mahamad Maifiah, Mohd Hafidz Ahfter, F. Hasan, Md Imran Farhad, Saif Uddin, Md. Rokib Ichwan, Solachuddin J. A. Ahmed, Qamar Uddin Bakhtiar, M. Taher Mawa, Imranul QD Chemistry RS403 Materia Medica-Pharmaceutical Chemistry S Agriculture (General) The WSE is a highly polar, gummy and mucilaginous bioactive content of the Nigella sativa (L.) seeds. This study reports the anxiolytic and anti-inflammatory effects of WSE investigated using Elevated Plus Maze (EPM) and Hole-Board Test (HBT) in adult mice and human RBCs haemolysis inhibition and protein denaturation respectively. The oral WSE treatment (100 & 200 mg/kg b.w/day) for 72 hours has exhibited slightly better anxiolytic effect (p < 0.05) through the time span (92.33 & 93.33 s) spent in the opened arms of EPM vs. diazepam (1 mg/kg b.w i.p/day; 69.33 s). In HBT, only WSE (200 mg/kg b.w/day) has shown a promising number of mean head pokes (13.27 times/min) vs. diazepam (12.87 times/min). The WSE (62.5-500 mg/mL) exposure has exhibited 40.14-72.18% protection against lysis of RBCs vs. aspirin (57.04-71.48%) whilst 62.67-67.66% inhibition of protein denaturation vs. diclofenac sodium (43.11-80.64%). The current findings suggested WSE has promising anxiolytic and anti-inflammatory activities. Taylor & Francis Online 2019-10-03 Article PeerReviewed application/pdf en http://irep.iium.edu.my/75208/1/75208_In%20vivo%20anxiolytic%20and%20in%20vitro.pdf application/pdf en http://irep.iium.edu.my/75208/2/75208_In%20vivo%20anxiolytic%20and%20in%20vitro_SCOPUS%20in%20press.pdf application/pdf en http://irep.iium.edu.my/75208/3/75208_In%20vivo%20anxiolytic%20and%20in%20vitro_WOS%20in%20press.pdf Mohammed Babar, Zahir Uddin and Jaswir, Irwandi and Tareq, Abu Montakim and Ali Reza, A. S. M. and Wan Sulaiman, Wan Mohd Azizi and Mahamad Maifiah, Mohd Hafidz and Ahfter, F. and Hasan, Md Imran and Farhad, Saif and Uddin, Md. Rokib and Ichwan, Solachuddin J. A. and Ahmed, Qamar Uddin and Bakhtiar, M. Taher and Mawa, Imranul (2019) In vivo anxiolytic and in vitro anti-inflammatory activities of water-soluble extract (WSE) of Nigella sativa (L.) seeds. Natural Product Research. pp. 1-6. ISSN 1478-6419 E-ISSN 1478-6427 https://doi.org/10.1080/14786419.2019.1667348 10.1080/14786419.2019.1667348
repository_type	Digital Repository
institution_category	Local University
institution	International Islamic University Malaysia
building	IIUM Repository
collection	Online Access
language	English English English
topic	QD Chemistry RS403 Materia Medica-Pharmaceutical Chemistry S Agriculture (General)
spellingShingle	QD Chemistry RS403 Materia Medica-Pharmaceutical Chemistry S Agriculture (General) Mohammed Babar, Zahir Uddin Jaswir, Irwandi Tareq, Abu Montakim Ali Reza, A. S. M. Wan Sulaiman, Wan Mohd Azizi Mahamad Maifiah, Mohd Hafidz Ahfter, F. Hasan, Md Imran Farhad, Saif Uddin, Md. Rokib Ichwan, Solachuddin J. A. Ahmed, Qamar Uddin Bakhtiar, M. Taher Mawa, Imranul In vivo anxiolytic and in vitro anti-inflammatory activities of water-soluble extract (WSE) of Nigella sativa (L.) seeds
description	The WSE is a highly polar, gummy and mucilaginous bioactive content of the Nigella sativa (L.) seeds. This study reports the anxiolytic and anti-inflammatory effects of WSE investigated using Elevated Plus Maze (EPM) and Hole-Board Test (HBT) in adult mice and human RBCs haemolysis inhibition and protein denaturation respectively. The oral WSE treatment (100 & 200 mg/kg b.w/day) for 72 hours has exhibited slightly better anxiolytic effect (p < 0.05) through the time span (92.33 & 93.33 s) spent in the opened arms of EPM vs. diazepam (1 mg/kg b.w i.p/day; 69.33 s). In HBT, only WSE (200 mg/kg b.w/day) has shown a promising number of mean head pokes (13.27 times/min) vs. diazepam (12.87 times/min). The WSE (62.5-500 mg/mL) exposure has exhibited 40.14-72.18% protection against lysis of RBCs vs. aspirin (57.04-71.48%) whilst 62.67-67.66% inhibition of protein denaturation vs. diclofenac sodium (43.11-80.64%). The current findings suggested WSE has promising anxiolytic and anti-inflammatory activities.
format	Article
author	Mohammed Babar, Zahir Uddin Jaswir, Irwandi Tareq, Abu Montakim Ali Reza, A. S. M. Wan Sulaiman, Wan Mohd Azizi Mahamad Maifiah, Mohd Hafidz Ahfter, F. Hasan, Md Imran Farhad, Saif Uddin, Md. Rokib Ichwan, Solachuddin J. A. Ahmed, Qamar Uddin Bakhtiar, M. Taher Mawa, Imranul
author_facet	Mohammed Babar, Zahir Uddin Jaswir, Irwandi Tareq, Abu Montakim Ali Reza, A. S. M. Wan Sulaiman, Wan Mohd Azizi Mahamad Maifiah, Mohd Hafidz Ahfter, F. Hasan, Md Imran Farhad, Saif Uddin, Md. Rokib Ichwan, Solachuddin J. A. Ahmed, Qamar Uddin Bakhtiar, M. Taher Mawa, Imranul
author_sort	Mohammed Babar, Zahir Uddin
title	In vivo anxiolytic and in vitro anti-inflammatory activities of water-soluble extract (WSE) of Nigella sativa (L.) seeds
title_short	In vivo anxiolytic and in vitro anti-inflammatory activities of water-soluble extract (WSE) of Nigella sativa (L.) seeds
title_full	In vivo anxiolytic and in vitro anti-inflammatory activities of water-soluble extract (WSE) of Nigella sativa (L.) seeds
title_fullStr	In vivo anxiolytic and in vitro anti-inflammatory activities of water-soluble extract (WSE) of Nigella sativa (L.) seeds
title_full_unstemmed	In vivo anxiolytic and in vitro anti-inflammatory activities of water-soluble extract (WSE) of Nigella sativa (L.) seeds
title_sort	in vivo anxiolytic and in vitro anti-inflammatory activities of water-soluble extract (wse) of nigella sativa (l.) seeds
publisher	Taylor & Francis Online
publishDate	2019
url	http://irep.iium.edu.my/75208/ http://irep.iium.edu.my/75208/ http://irep.iium.edu.my/75208/ http://irep.iium.edu.my/75208/1/75208_In%20vivo%20anxiolytic%20and%20in%20vitro.pdf http://irep.iium.edu.my/75208/2/75208_In%20vivo%20anxiolytic%20and%20in%20vitro_SCOPUS%20in%20press.pdf http://irep.iium.edu.my/75208/3/75208_In%20vivo%20anxiolytic%20and%20in%20vitro_WOS%20in%20press.pdf
first_indexed	2023-09-18T21:46:24Z
last_indexed	2023-09-18T21:46:24Z
_version_	1777413479121027072

In vivo anxiolytic and in vitro anti-inflammatory activities of water-soluble extract (WSE) of Nigella sativa (L.) seeds

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