Potential applications of horseshoe crab in biomedical research

Horseshoe crab is one of the oldest existing living fossils comprising four main species today. Of these, Limulus Polyphemus is found in North America and the other three species, Tachypleus tridentatus, Tachypleus gigas and Carcinoscorpius rotundicauda are found in Southeast Asia. Horseshoe crabs p...

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Main Authors:	Ibrahim, Najian, Kannan, Thirumulu Ponnuraj, Ahmad, Azlina, Mokhtar@Makhtar, Khairani Idah
Format:	Article
Language:	English
Published:	Advanced Medical and Dental Institute (AMDI, USM) 2019
Subjects:	RK Dentistry
Online Access:	http://irep.iium.edu.my/77573/ http://irep.iium.edu.my/77573/ http://irep.iium.edu.my/77573/1/Najian%20et%20al%202019-%20Potential%20applications%20of%20horseshoe%20crab%20in%20biomedical.pdf

id	iium-77573
recordtype	eprints
spelling	iium-775732020-01-10T07:42:45Z http://irep.iium.edu.my/77573/ Potential applications of horseshoe crab in biomedical research Ibrahim, Najian Kannan, Thirumulu Ponnuraj Ahmad, Azlina Mokhtar@Makhtar, Khairani Idah RK Dentistry Horseshoe crab is one of the oldest existing living fossils comprising four main species today. Of these, Limulus Polyphemus is found in North America and the other three species, Tachypleus tridentatus, Tachypleus gigas and Carcinoscorpius rotundicauda are found in Southeast Asia. Horseshoe crabs play important roles in the regulation of the coastal ecology communities whereby the eggs serve as the main diet of shorebird species during the migrating season. Horseshoe crab is also seen as a versatile organism, useful in the biomedicine field particularly, as its blue blood has been widely integrated to be used for endotoxin tester in vaccines, drugs and injectables. Researchers have explored a material called perivitelline fluid (PVF) from the egg of a fertilized horseshoe crab which is rich in important proteins and amino acids that are crucial for embryogenesis. Previous studies have shown that PVF has the ability to enhance cell growth and differentiation as well as in promoting generation of certain organs. Testing of PVF on many types of cells has shown positive results and hence, it is suggested that PVF could be used as a supplement to support cell growth in future. Highlighting the horseshoe crab as a living fossil, this review brings out the relevance of the blue blood and PVF of the horseshoe crab as sources benefitting molecular research. Advanced Medical and Dental Institute (AMDI, USM) 2019-12 Article PeerReviewed application/pdf en http://irep.iium.edu.my/77573/1/Najian%20et%20al%202019-%20Potential%20applications%20of%20horseshoe%20crab%20in%20biomedical.pdf Ibrahim, Najian and Kannan, Thirumulu Ponnuraj and Ahmad, Azlina and Mokhtar@Makhtar, Khairani Idah (2019) Potential applications of horseshoe crab in biomedical research. Journal of Biomedical & Clinical Science, 4 (2). pp. 12-18. E-ISSN 2550-147X http://apps.amdi.usm.my/journal/index.php/jbcs/article/view/202/pdf
repository_type	Digital Repository
institution_category	Local University
institution	International Islamic University Malaysia
building	IIUM Repository
collection	Online Access
language	English
topic	RK Dentistry
spellingShingle	RK Dentistry Ibrahim, Najian Kannan, Thirumulu Ponnuraj Ahmad, Azlina Mokhtar@Makhtar, Khairani Idah Potential applications of horseshoe crab in biomedical research
description	Horseshoe crab is one of the oldest existing living fossils comprising four main species today. Of these, Limulus Polyphemus is found in North America and the other three species, Tachypleus tridentatus, Tachypleus gigas and Carcinoscorpius rotundicauda are found in Southeast Asia. Horseshoe crabs play important roles in the regulation of the coastal ecology communities whereby the eggs serve as the main diet of shorebird species during the migrating season. Horseshoe crab is also seen as a versatile organism, useful in the biomedicine field particularly, as its blue blood has been widely integrated to be used for endotoxin tester in vaccines, drugs and injectables. Researchers have explored a material called perivitelline fluid (PVF) from the egg of a fertilized horseshoe crab which is rich in important proteins and amino acids that are crucial for embryogenesis. Previous studies have shown that PVF has the ability to enhance cell growth and differentiation as well as in promoting generation of certain organs. Testing of PVF on many types of cells has shown positive results and hence, it is suggested that PVF could be used as a supplement to support cell growth in future. Highlighting the horseshoe crab as a living fossil, this review brings out the relevance of the blue blood and PVF of the horseshoe crab as sources benefitting molecular research.
format	Article
author	Ibrahim, Najian Kannan, Thirumulu Ponnuraj Ahmad, Azlina Mokhtar@Makhtar, Khairani Idah
author_facet	Ibrahim, Najian Kannan, Thirumulu Ponnuraj Ahmad, Azlina Mokhtar@Makhtar, Khairani Idah
author_sort	Ibrahim, Najian
title	Potential applications of horseshoe crab in biomedical research
title_short	Potential applications of horseshoe crab in biomedical research
title_full	Potential applications of horseshoe crab in biomedical research
title_fullStr	Potential applications of horseshoe crab in biomedical research
title_full_unstemmed	Potential applications of horseshoe crab in biomedical research
title_sort	potential applications of horseshoe crab in biomedical research
publisher	Advanced Medical and Dental Institute (AMDI, USM)
publishDate	2019
url	http://irep.iium.edu.my/77573/ http://irep.iium.edu.my/77573/ http://irep.iium.edu.my/77573/1/Najian%20et%20al%202019-%20Potential%20applications%20of%20horseshoe%20crab%20in%20biomedical.pdf
first_indexed	2023-09-18T21:49:24Z
last_indexed	2023-09-18T21:49:24Z
_version_	1777413667988439040

Potential applications of horseshoe crab in biomedical research

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