Epithelial to mesenchymal transition and eepithelialisation in wound healing: a review of comparison

Skin wound healing is a complex physiological event, involving many cellular and molecular components. The event of wound healing is the coordinated overlap of a number of distinct phases, namely haemostasis, inflammatory, proliferative and remodelling. The molecular events surrounding wound healing...

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Main Authors:	Abid Nordin, Shiplu Roy Chowdhury, Aminuddin Saim, Ruszymah Hj Idrus
Format:	Article
Language:	English
Published:	Penerbit Universiti Kebangsaan Malaysia 2018
Online Access:	http://journalarticle.ukm.my/12517/ http://journalarticle.ukm.my/12517/ http://journalarticle.ukm.my/12517/1/23%20Abid%20Nordin.pdf

id	ukm-12517
recordtype	eprints
spelling	ukm-125172019-01-28T21:29:53Z http://journalarticle.ukm.my/12517/ Epithelial to mesenchymal transition and eepithelialisation in wound healing: a review of comparison Abid Nordin, Shiplu Roy Chowdhury, Aminuddin Saim, Ruszymah Hj Idrus, Skin wound healing is a complex physiological event, involving many cellular and molecular components. The event of wound healing is the coordinated overlap of a number of distinct phases, namely haemostasis, inflammatory, proliferative and remodelling. The molecular events surrounding wound healing, particularly the reepithelialisation, has been reported to be similar to the epithelial to mesenchymal transition (EMT). In this review, the mechanism between epithelialisation and EMT were compared. Both are characterised by the loss of epithelial integrity and increased motility. In terms of the signalling kinases, Smad and mitogen-activated protein kinase (MAPK) has been reported to be involved in both reepithelialisation and EMT. At the transcriptional level, SLUG transcription factor has been reported to be important for both reepithelialisation and EMT. Extracellular matrix proteins that have been associated with both events are collagen and laminin. Lastly, both events required the interplay between matrix metalloproteinases (MMPs) and its inhibitor. As a conclusion, both reepithelialisation and EMT shares similar signaling cascade and transcriptional regulation to exhibit decreased epithelial traits and increased motility in keratinocytes. Penerbit Universiti Kebangsaan Malaysia 2018-10 Article PeerReviewed application/pdf en http://journalarticle.ukm.my/12517/1/23%20Abid%20Nordin.pdf Abid Nordin, and Shiplu Roy Chowdhury, and Aminuddin Saim, and Ruszymah Hj Idrus, (2018) Epithelial to mesenchymal transition and eepithelialisation in wound healing: a review of comparison. Sains Malaysiana, 47 (10). pp. 2463-2471. ISSN 0126-6039 http://www.ukm.my/jsm/malay_journals/jilid47bil10_2018/KandunganJilid47Bil10_2018.htm
repository_type	Digital Repository
institution_category	Local University
institution	Universiti Kebangasaan Malaysia
building	UKM Institutional Repository
collection	Online Access
language	English
description	Skin wound healing is a complex physiological event, involving many cellular and molecular components. The event of wound healing is the coordinated overlap of a number of distinct phases, namely haemostasis, inflammatory, proliferative and remodelling. The molecular events surrounding wound healing, particularly the reepithelialisation, has been reported to be similar to the epithelial to mesenchymal transition (EMT). In this review, the mechanism between epithelialisation and EMT were compared. Both are characterised by the loss of epithelial integrity and increased motility. In terms of the signalling kinases, Smad and mitogen-activated protein kinase (MAPK) has been reported to be involved in both reepithelialisation and EMT. At the transcriptional level, SLUG transcription factor has been reported to be important for both reepithelialisation and EMT. Extracellular matrix proteins that have been associated with both events are collagen and laminin. Lastly, both events required the interplay between matrix metalloproteinases (MMPs) and its inhibitor. As a conclusion, both reepithelialisation and EMT shares similar signaling cascade and transcriptional regulation to exhibit decreased epithelial traits and increased motility in keratinocytes.
format	Article
author	Abid Nordin, Shiplu Roy Chowdhury, Aminuddin Saim, Ruszymah Hj Idrus,
spellingShingle	Abid Nordin, Shiplu Roy Chowdhury, Aminuddin Saim, Ruszymah Hj Idrus, Epithelial to mesenchymal transition and eepithelialisation in wound healing: a review of comparison
author_facet	Abid Nordin, Shiplu Roy Chowdhury, Aminuddin Saim, Ruszymah Hj Idrus,
author_sort	Abid Nordin,
title	Epithelial to mesenchymal transition and eepithelialisation in wound healing: a review of comparison
title_short	Epithelial to mesenchymal transition and eepithelialisation in wound healing: a review of comparison
title_full	Epithelial to mesenchymal transition and eepithelialisation in wound healing: a review of comparison
title_fullStr	Epithelial to mesenchymal transition and eepithelialisation in wound healing: a review of comparison
title_full_unstemmed	Epithelial to mesenchymal transition and eepithelialisation in wound healing: a review of comparison
title_sort	epithelial to mesenchymal transition and eepithelialisation in wound healing: a review of comparison
publisher	Penerbit Universiti Kebangsaan Malaysia
publishDate	2018
url	http://journalarticle.ukm.my/12517/ http://journalarticle.ukm.my/12517/ http://journalarticle.ukm.my/12517/1/23%20Abid%20Nordin.pdf
first_indexed	2023-09-18T20:02:47Z
last_indexed	2023-09-18T20:02:47Z
_version_	1777406960071606272

Epithelial to mesenchymal transition and eepithelialisation in wound healing: a review of comparison

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