In silico homology modelling and identification of Tousled-like kinase 1 inhibitors for glioblastoma therapy via high throughput virtual screening protein-ligand docking

Glioblastoma multiforme (GBM) is a high-grade brain tumor of which the survival patients remain poor. Tousled-like kinase 1 (TLK1), a serine-threonine kinase, was identified to be overexpressed in cancers such as GBM. TLK1 plays an important role in controlling survival pathways. To date, there is n...

Full description

Bibliographic Details
Main Authors: Kamariah Ibrahim, Abubakar Danjuma Abdullahi, Nor Azian Abdul Murad, Roslan Harun, Rahman Jamal
Format: Article
Language:English
Published: Pusat Perubatan Universiti Kebangsaan Malaysia 2018
Online Access:http://journalarticle.ukm.my/13245/
http://journalarticle.ukm.my/13245/
http://journalarticle.ukm.my/13245/1/38-134-1-PB.pdf