Association between polymorphisms of insulin and insulin receptor gene with childhood obesity in Malay population

Childhood obesity is a global epidemic, which leads to the increasing number of studies on genetic locations associated with obesity-related traits. Polymorphisms of insulin (INS) gene have been shown to be associated with obesity-related phenotypes in Europeans; while insulin receptor (INSR) gene...

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Main Authors:	Pey, Christinal Wen Teh, Nurul Adibah Nizam, Pei, Nee Chong, Abdul Rahman Jamal, Bee, Koon Poh, Wan Zurinah Wan Ngah
Format:	Article
Language:	English
Published:	Penerbit UKM 2016
Online Access:	http://journalarticle.ukm.my/9723/ http://journalarticle.ukm.my/9723/ http://journalarticle.ukm.my/9723/1/12262-33447-1-SM.pdf

id	ukm-9723
recordtype	eprints
spelling	ukm-97232016-12-14T06:50:39Z http://journalarticle.ukm.my/9723/ Association between polymorphisms of insulin and insulin receptor gene with childhood obesity in Malay population Pey, Christinal Wen Teh Nurul Adibah Nizam, Pei, Nee Chong Abdul Rahman Jamal, Bee, Koon Poh Wan Zurinah Wan Ngah, Childhood obesity is a global epidemic, which leads to the increasing number of studies on genetic locations associated with obesity-related traits. Polymorphisms of insulin (INS) gene have been shown to be associated with obesity-related phenotypes in Europeans; while insulin receptor (INSR) gene has been associated with energy regulation. Therefore, this study was conducted to investigate the association between the INS (rs689) and INSR (rs3745551) gene polymorphisms with childhood obesity risk in a Malay childhood population. Normal weight (538) and overweight or obese (557) children aged 6-12 years old were genotyped using semi-automated Sequenom iPLEX® Gold. Body mass index (BMI) was calculated from measured body weight and height. The rs689 (T/T: 0.006, A/T: 0.159 and A/A: 0.835) and rs3745551 (G/G: 0.054, A/G: 0.378 and A/A: 0.568) genotype distributions were consistent with Hardy Weinberg equilibrium. The T-minor allele frequency for rs689 was 8.6% and G-minor allele frequency for rs3745551 was 24.3%. Minor allele of INS gene polymorphisms significantly increased risk of obesity among Malay children (sex- and age-adjusted OR=1.580; 95%CI: 1.134-2.201). However, INSR gene polymorphisms were not significantly associated with childhood obesity. In conclusion, the polymorphisms of INS gene, rather than INSR gene, were associated with childhood obesity in the Malay population. Penerbit UKM 2016 Article PeerReviewed application/pdf en http://journalarticle.ukm.my/9723/1/12262-33447-1-SM.pdf Pey, Christinal Wen Teh and Nurul Adibah Nizam, and Pei, Nee Chong and Abdul Rahman Jamal, and Bee, Koon Poh and Wan Zurinah Wan Ngah, (2016) Association between polymorphisms of insulin and insulin receptor gene with childhood obesity in Malay population. Jurnal Sains Kesihatan Malaysia, 14 (1). pp. 5-9. ISSN 1675-8161 http://ejournal.ukm.my/jskm/issue/view/633
repository_type	Digital Repository
institution_category	Local University
institution	Universiti Kebangasaan Malaysia
building	UKM Institutional Repository
collection	Online Access
language	English
description	Childhood obesity is a global epidemic, which leads to the increasing number of studies on genetic locations associated with obesity-related traits. Polymorphisms of insulin (INS) gene have been shown to be associated with obesity-related phenotypes in Europeans; while insulin receptor (INSR) gene has been associated with energy regulation. Therefore, this study was conducted to investigate the association between the INS (rs689) and INSR (rs3745551) gene polymorphisms with childhood obesity risk in a Malay childhood population. Normal weight (538) and overweight or obese (557) children aged 6-12 years old were genotyped using semi-automated Sequenom iPLEX® Gold. Body mass index (BMI) was calculated from measured body weight and height. The rs689 (T/T: 0.006, A/T: 0.159 and A/A: 0.835) and rs3745551 (G/G: 0.054, A/G: 0.378 and A/A: 0.568) genotype distributions were consistent with Hardy Weinberg equilibrium. The T-minor allele frequency for rs689 was 8.6% and G-minor allele frequency for rs3745551 was 24.3%. Minor allele of INS gene polymorphisms significantly increased risk of obesity among Malay children (sex- and age-adjusted OR=1.580; 95%CI: 1.134-2.201). However, INSR gene polymorphisms were not significantly associated with childhood obesity. In conclusion, the polymorphisms of INS gene, rather than INSR gene, were associated with childhood obesity in the Malay population.
format	Article
author	Pey, Christinal Wen Teh Nurul Adibah Nizam, Pei, Nee Chong Abdul Rahman Jamal, Bee, Koon Poh Wan Zurinah Wan Ngah,
spellingShingle	Pey, Christinal Wen Teh Nurul Adibah Nizam, Pei, Nee Chong Abdul Rahman Jamal, Bee, Koon Poh Wan Zurinah Wan Ngah, Association between polymorphisms of insulin and insulin receptor gene with childhood obesity in Malay population
author_facet	Pey, Christinal Wen Teh Nurul Adibah Nizam, Pei, Nee Chong Abdul Rahman Jamal, Bee, Koon Poh Wan Zurinah Wan Ngah,
author_sort	Pey, Christinal Wen Teh
title	Association between polymorphisms of insulin and insulin receptor gene with childhood obesity in Malay population
title_short	Association between polymorphisms of insulin and insulin receptor gene with childhood obesity in Malay population
title_full	Association between polymorphisms of insulin and insulin receptor gene with childhood obesity in Malay population
title_fullStr	Association between polymorphisms of insulin and insulin receptor gene with childhood obesity in Malay population
title_full_unstemmed	Association between polymorphisms of insulin and insulin receptor gene with childhood obesity in Malay population
title_sort	association between polymorphisms of insulin and insulin receptor gene with childhood obesity in malay population
publisher	Penerbit UKM
publishDate	2016
url	http://journalarticle.ukm.my/9723/ http://journalarticle.ukm.my/9723/ http://journalarticle.ukm.my/9723/1/12262-33447-1-SM.pdf
first_indexed	2023-09-18T19:55:32Z
last_indexed	2023-09-18T19:55:32Z
_version_	1777406503739719680

Association between polymorphisms of insulin and insulin receptor gene with childhood obesity in Malay population

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