Antimicrobial peptides as an alternative to anti-tuberculosis drugs

Tuberculosis (TB) presently accounts for high global mortality and morbidity rates, despite the introduction four decades ago of the affordable and efficient four-drugs (isoniazid, rifampicin, pyrazinamide and ethambutol). Thus, a strong need exists for new drugs with special structures and uncommon...

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Main Authors:	Almatar, Manaf, Makky, Essam A., Yakici, Gulfer, Var, Isil, Kayar, Begum, Koksal, Fatih
Format:	Article
Language:	English
Published:	Elsevier 2018
Subjects:	Q Science (General)
Online Access:	http://umpir.ump.edu.my/id/eprint/19672/ http://umpir.ump.edu.my/id/eprint/19672/ http://umpir.ump.edu.my/id/eprint/19672/ http://umpir.ump.edu.my/id/eprint/19672/1/Antimicrobial%20peptides%20as%20an%20alternative%20to%20anti-tuberculosis%20drugs-fist-2018.pdf

id	ump-19672
recordtype	eprints
spelling	ump-196722018-06-04T07:42:50Z http://umpir.ump.edu.my/id/eprint/19672/ Antimicrobial peptides as an alternative to anti-tuberculosis drugs Almatar, Manaf Makky, Essam A. Yakici, Gulfer Var, Isil Kayar, Begum Koksal, Fatih Q Science (General) Tuberculosis (TB) presently accounts for high global mortality and morbidity rates, despite the introduction four decades ago of the affordable and efficient four-drugs (isoniazid, rifampicin, pyrazinamide and ethambutol). Thus, a strong need exists for new drugs with special structures and uncommon modes of action to effectively overcome M. tuberculosis. Within this scope, antimicrobial peptides (AMPs), which are small, cationic and amphipathic peptides that comprise a section of the innate immune system, are currently the leading potential agents for the treatment of TB. Many studies have recently illustrated the capability of anti-mycobacterial peptides to disrupt the normal mycobacterial cell wall function through various modes, thereby interacting with the intracellular targets, as well as encompassing nucleic acids, enzymes and organelles. This review presents a wide array of antimicrobial activities, alongside the associated properties of the AMPs that could be utilized as potential agents in therapeutic tactics for TB treatment. Elsevier 2018 Article PeerReviewed application/pdf en http://umpir.ump.edu.my/id/eprint/19672/1/Antimicrobial%20peptides%20as%20an%20alternative%20to%20anti-tuberculosis%20drugs-fist-2018.pdf Almatar, Manaf and Makky, Essam A. and Yakici, Gulfer and Var, Isil and Kayar, Begum and Koksal, Fatih (2018) Antimicrobial peptides as an alternative to anti-tuberculosis drugs. Pharmacological Research, 128. pp. 288-305. ISSN 1043-6618 https://doi.org/10.1016/j.phrs.2017.10.011 doi: 10.1016/j.phrs.2017.10.011
repository_type	Digital Repository
institution_category	Local University
institution	Universiti Malaysia Pahang
building	UMP Institutional Repository
collection	Online Access
language	English
topic	Q Science (General)
spellingShingle	Q Science (General) Almatar, Manaf Makky, Essam A. Yakici, Gulfer Var, Isil Kayar, Begum Koksal, Fatih Antimicrobial peptides as an alternative to anti-tuberculosis drugs
description	Tuberculosis (TB) presently accounts for high global mortality and morbidity rates, despite the introduction four decades ago of the affordable and efficient four-drugs (isoniazid, rifampicin, pyrazinamide and ethambutol). Thus, a strong need exists for new drugs with special structures and uncommon modes of action to effectively overcome M. tuberculosis. Within this scope, antimicrobial peptides (AMPs), which are small, cationic and amphipathic peptides that comprise a section of the innate immune system, are currently the leading potential agents for the treatment of TB. Many studies have recently illustrated the capability of anti-mycobacterial peptides to disrupt the normal mycobacterial cell wall function through various modes, thereby interacting with the intracellular targets, as well as encompassing nucleic acids, enzymes and organelles. This review presents a wide array of antimicrobial activities, alongside the associated properties of the AMPs that could be utilized as potential agents in therapeutic tactics for TB treatment.
format	Article
author	Almatar, Manaf Makky, Essam A. Yakici, Gulfer Var, Isil Kayar, Begum Koksal, Fatih
author_facet	Almatar, Manaf Makky, Essam A. Yakici, Gulfer Var, Isil Kayar, Begum Koksal, Fatih
author_sort	Almatar, Manaf
title	Antimicrobial peptides as an alternative to anti-tuberculosis drugs
title_short	Antimicrobial peptides as an alternative to anti-tuberculosis drugs
title_full	Antimicrobial peptides as an alternative to anti-tuberculosis drugs
title_fullStr	Antimicrobial peptides as an alternative to anti-tuberculosis drugs
title_full_unstemmed	Antimicrobial peptides as an alternative to anti-tuberculosis drugs
title_sort	antimicrobial peptides as an alternative to anti-tuberculosis drugs
publisher	Elsevier
publishDate	2018
url	http://umpir.ump.edu.my/id/eprint/19672/ http://umpir.ump.edu.my/id/eprint/19672/ http://umpir.ump.edu.my/id/eprint/19672/ http://umpir.ump.edu.my/id/eprint/19672/1/Antimicrobial%20peptides%20as%20an%20alternative%20to%20anti-tuberculosis%20drugs-fist-2018.pdf
first_indexed	2023-09-18T22:28:09Z
last_indexed	2023-09-18T22:28:09Z
_version_	1777416106061856768

Antimicrobial peptides as an alternative to anti-tuberculosis drugs

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