Design and synthesis of a novel mPGES-1 lead inhibitor guided by 3D-QSAR CoMFA

Design and synthesis of a novel mPGES-1 lead inhibitor guided by 3D-QSAR CoMFA

The search of novel mPGES-1 inhibitors has recently intensified probably due to the superior safety in comparison to existing anti-inflammatory drugs. Although two mPGES-1 inhibitors have entered clinical trials, none has yet reached the market. In this study, we performed modifications guided by 3D...

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Bibliographic Details
Main Authors: Mohd F. F., Mohd Aluwi, Rullah, Kamal, Koeberle, Andreas, Werz, Oliver, Nur Sakinah, Abdul Razak, Wei, Leong Sze, Fatimah, Salim, Nor Hadiani, Ismail, Ibrahim, Jantan, Wai, Lam K.
Format: Article
Language:English
Published: Elsevier Ltd 2019
Subjects:
R Medicine (General)
RM Therapeutics. Pharmacology
RS Pharmacy and materia medica
Online Access:http://umpir.ump.edu.my/id/eprint/25636/
http://umpir.ump.edu.my/id/eprint/25636/
http://umpir.ump.edu.my/id/eprint/25636/
http://umpir.ump.edu.my/id/eprint/25636/1/Design%20and%20synthesis%20of%20a%20novel%20mPGES-1%20lead%20inhibitor%20.pdf

Internet

http://umpir.ump.edu.my/id/eprint/25636/
http://umpir.ump.edu.my/id/eprint/25636/
http://umpir.ump.edu.my/id/eprint/25636/
http://umpir.ump.edu.my/id/eprint/25636/1/Design%20and%20synthesis%20of%20a%20novel%20mPGES-1%20lead%20inhibitor%20.pdf

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