Cladosporium Cladosporioides from the Perspectives of Medical and Biotechnological Approaches

Fungi are important natural product sources that have enormous potential for the production of novel compounds for use in pharmacology, agricultural applications and industry. Compared with other natural sources such as plants, fungi are highly diverse but understudied. However, research on Cladospo...

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Main Authors:	Almatar, Manaf, Makky, Essam A.
Format:	Article
Language:	English English
Published:	Springer Berlin Heidelberg 2016
Subjects:	Q Science (General)
Online Access:	http://umpir.ump.edu.my/id/eprint/8222/ http://umpir.ump.edu.my/id/eprint/8222/ http://umpir.ump.edu.my/id/eprint/8222/ http://umpir.ump.edu.my/id/eprint/8222/7/Cladosporium%20Cladosporioides%20from%20the%20Perspectives%20of%20Medical%20and%20Biotechnological%20Approaches.pdf http://umpir.ump.edu.my/id/eprint/8222/13/3Biotech_Sprimger_2016.pdf

id	ump-8222
recordtype	eprints
spelling	ump-82222018-01-10T05:51:38Z http://umpir.ump.edu.my/id/eprint/8222/ Cladosporium Cladosporioides from the Perspectives of Medical and Biotechnological Approaches Almatar, Manaf Makky, Essam A. Q Science (General) Fungi are important natural product sources that have enormous potential for the production of novel compounds for use in pharmacology, agricultural applications and industry. Compared with other natural sources such as plants, fungi are highly diverse but understudied. However, research on Cladosporium cladosporioides revealed the existence of bioactive products such as p-methylbenzoic acid, ergosterol peroxide (EP) and calphostin C as well as enzymes including pectin methylesterase (PME), polygalacturonase (PG) and chlorpyrifos hydrolase. p-Methylbenzoic acid has ability to synthesise 1,5-benzodiazepine and its derivatives, polyethylene terephthalate and eicosapentaenoic acid. EP has anticancer, antiangiogenic, antibacterial, anti-oxidative and immunosuppressive properties. Calphostin C inhibits protein kinase C (PKC) by inactivating both PKC-epsilon and PKC-alpha. In addition, calphostin C stimulates apoptosis in WEHI-231 cells and vascular smooth muscle cells. Based on the stimulation of endoplasmic reticulum stress in some types of cancer, calphostin C has also been evaluated as a potential photodynamic therapeutic agent. Methylesterase (PME) and PG have garnered attention because of their usage in the food processing industry and significant physiological function in plants. Chlorpyrifos, a human, animal and plant toxin, can be degraded and eliminated by chlorpyrifos hydrolase. Springer Berlin Heidelberg 2016 Article PeerReviewed application/pdf en http://umpir.ump.edu.my/id/eprint/8222/7/Cladosporium%20Cladosporioides%20from%20the%20Perspectives%20of%20Medical%20and%20Biotechnological%20Approaches.pdf application/pdf en http://umpir.ump.edu.my/id/eprint/8222/13/3Biotech_Sprimger_2016.pdf Almatar, Manaf and Makky, Essam A. (2016) Cladosporium Cladosporioides from the Perspectives of Medical and Biotechnological Approaches. 3 Biotech, 6 (4). pp. 1-8. ISSN 2190-572X (print); 2190-5738 (online) http://dx.doi.org/10.1007/s13205-015-0323-4 DOI: 10.1007/s13205-015-0323-4
repository_type	Digital Repository
institution_category	Local University
institution	Universiti Malaysia Pahang
building	UMP Institutional Repository
collection	Online Access
language	English English
topic	Q Science (General)
spellingShingle	Q Science (General) Almatar, Manaf Makky, Essam A. Cladosporium Cladosporioides from the Perspectives of Medical and Biotechnological Approaches
description	Fungi are important natural product sources that have enormous potential for the production of novel compounds for use in pharmacology, agricultural applications and industry. Compared with other natural sources such as plants, fungi are highly diverse but understudied. However, research on Cladosporium cladosporioides revealed the existence of bioactive products such as p-methylbenzoic acid, ergosterol peroxide (EP) and calphostin C as well as enzymes including pectin methylesterase (PME), polygalacturonase (PG) and chlorpyrifos hydrolase. p-Methylbenzoic acid has ability to synthesise 1,5-benzodiazepine and its derivatives, polyethylene terephthalate and eicosapentaenoic acid. EP has anticancer, antiangiogenic, antibacterial, anti-oxidative and immunosuppressive properties. Calphostin C inhibits protein kinase C (PKC) by inactivating both PKC-epsilon and PKC-alpha. In addition, calphostin C stimulates apoptosis in WEHI-231 cells and vascular smooth muscle cells. Based on the stimulation of endoplasmic reticulum stress in some types of cancer, calphostin C has also been evaluated as a potential photodynamic therapeutic agent. Methylesterase (PME) and PG have garnered attention because of their usage in the food processing industry and significant physiological function in plants. Chlorpyrifos, a human, animal and plant toxin, can be degraded and eliminated by chlorpyrifos hydrolase.
format	Article
author	Almatar, Manaf Makky, Essam A.
author_facet	Almatar, Manaf Makky, Essam A.
author_sort	Almatar, Manaf
title	Cladosporium Cladosporioides from the Perspectives of Medical and Biotechnological Approaches
title_short	Cladosporium Cladosporioides from the Perspectives of Medical and Biotechnological Approaches
title_full	Cladosporium Cladosporioides from the Perspectives of Medical and Biotechnological Approaches
title_fullStr	Cladosporium Cladosporioides from the Perspectives of Medical and Biotechnological Approaches
title_full_unstemmed	Cladosporium Cladosporioides from the Perspectives of Medical and Biotechnological Approaches
title_sort	cladosporium cladosporioides from the perspectives of medical and biotechnological approaches
publisher	Springer Berlin Heidelberg
publishDate	2016
url	http://umpir.ump.edu.my/id/eprint/8222/ http://umpir.ump.edu.my/id/eprint/8222/ http://umpir.ump.edu.my/id/eprint/8222/ http://umpir.ump.edu.my/id/eprint/8222/7/Cladosporium%20Cladosporioides%20from%20the%20Perspectives%20of%20Medical%20and%20Biotechnological%20Approaches.pdf http://umpir.ump.edu.my/id/eprint/8222/13/3Biotech_Sprimger_2016.pdf
first_indexed	2023-09-18T22:05:34Z
last_indexed	2023-09-18T22:05:34Z
_version_	1777414684610134016

Cladosporium Cladosporioides from the Perspectives of Medical and Biotechnological Approaches

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