Extraction of α-glucosidase inhibitory compounds from Phaleria macrocarpa fruit flesh using solvent, sonication, and subcritical carbon dioxide soxhlet methods

The objective of this study was to compare a-glucosidase inhibitory activity of Phaleria macrocarpa extracts using subcritical carbon dioxide (subCO2) soxhlet extraction method with sonication and solvent extraction methods. The extraction was performed by subCO2 soxlet using carbon dioxide and t...

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Main Authors:	Easmin, Sabina, Sarker, Md. Zaidul Islam, Ghafoor, Kashif, Ferdosh, Sahena, Jaffri, J. M., Akanda, Md. Jahurul Haque, Al-Juhaimi, Fahad Y., Bostanudin, M. Fauzi, Khatib, Alfi
Format:	Article
Language:	English English
Published:	Wiley-Blackwell Publishing Ltd 2017
Subjects:	RS403 Materia Medica-Pharmaceutical Chemistry
Online Access:	http://irep.iium.edu.my/59137/ http://irep.iium.edu.my/59137/ http://irep.iium.edu.my/59137/ http://irep.iium.edu.my/59137/1/easmin2017.pdf http://irep.iium.edu.my/59137/7/Extraction%20of%20a-glucosidase%20inhibitory%20compounds%20from.pdf

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spelling	iium-591372018-04-25T07:38:33Z http://irep.iium.edu.my/59137/ Extraction of α-glucosidase inhibitory compounds from Phaleria macrocarpa fruit flesh using solvent, sonication, and subcritical carbon dioxide soxhlet methods Easmin, Sabina Sarker, Md. Zaidul Islam Ghafoor, Kashif Ferdosh, Sahena Jaffri, J. M. Akanda, Md. Jahurul Haque Al-Juhaimi, Fahad Y. Bostanudin, M. Fauzi Khatib, Alfi RS403 Materia Medica-Pharmaceutical Chemistry The objective of this study was to compare a-glucosidase inhibitory activity of Phaleria macrocarpa extracts using subcritical carbon dioxide (subCO2) soxhlet extraction method with sonication and solvent extraction methods. The extraction was performed by subCO2 soxlet using carbon dioxide and the conventional organic solvent-based sonication using ethanol and water, solvent extraction using methanol, and n-hexane solvents. The yields and a-glucosidase inhibitory activity of the P. macrocarpa extracts were analyzed. The yields using sonication, solvent extraction, and subCO2 soxhlet extraction were approximately 10.261.0 to 25.460.6% and 0.960.1 to 2.061.0%. The IC50 value of subCO2 soxhlet, sonication, and solvent extraction methods were 4.35, 7.34, and 1.9 mg/mL, respectively. The a-glucosidase inhibitory activity of P. macrocarpa extract using subCO2 soxhlet method was higher than the conventional sonication method and lower than the solvent extraction method. Overall, subCO2 soxhlet extraction of P. macrocarpa represents a promising method to produce organic solvent free and highly a-glucosidase inhibitory compounds containing extracts. Wiley-Blackwell Publishing Ltd 2017-10 Article PeerReviewed application/pdf en http://irep.iium.edu.my/59137/1/easmin2017.pdf application/pdf en http://irep.iium.edu.my/59137/7/Extraction%20of%20a-glucosidase%20inhibitory%20compounds%20from.pdf Easmin, Sabina and Sarker, Md. Zaidul Islam and Ghafoor, Kashif and Ferdosh, Sahena and Jaffri, J. M. and Akanda, Md. Jahurul Haque and Al-Juhaimi, Fahad Y. and Bostanudin, M. Fauzi and Khatib, Alfi (2017) Extraction of α-glucosidase inhibitory compounds from Phaleria macrocarpa fruit flesh using solvent, sonication, and subcritical carbon dioxide soxhlet methods. Journal of Food Biochemistry, 41 (5). pp. 1-11. ISSN 0145-8884 http://onlinelibrary.wiley.com/doi/10.1111/jfbc.12399/abstract 10.1111/jfbc.12399
repository_type	Digital Repository
institution_category	Local University
institution	International Islamic University Malaysia
building	IIUM Repository
collection	Online Access
language	English English
topic	RS403 Materia Medica-Pharmaceutical Chemistry
spellingShingle	RS403 Materia Medica-Pharmaceutical Chemistry Easmin, Sabina Sarker, Md. Zaidul Islam Ghafoor, Kashif Ferdosh, Sahena Jaffri, J. M. Akanda, Md. Jahurul Haque Al-Juhaimi, Fahad Y. Bostanudin, M. Fauzi Khatib, Alfi Extraction of α-glucosidase inhibitory compounds from Phaleria macrocarpa fruit flesh using solvent, sonication, and subcritical carbon dioxide soxhlet methods
description	The objective of this study was to compare a-glucosidase inhibitory activity of Phaleria macrocarpa extracts using subcritical carbon dioxide (subCO2) soxhlet extraction method with sonication and solvent extraction methods. The extraction was performed by subCO2 soxlet using carbon dioxide and the conventional organic solvent-based sonication using ethanol and water, solvent extraction using methanol, and n-hexane solvents. The yields and a-glucosidase inhibitory activity of the P. macrocarpa extracts were analyzed. The yields using sonication, solvent extraction, and subCO2 soxhlet extraction were approximately 10.261.0 to 25.460.6% and 0.960.1 to 2.061.0%. The IC50 value of subCO2 soxhlet, sonication, and solvent extraction methods were 4.35, 7.34, and 1.9 mg/mL, respectively. The a-glucosidase inhibitory activity of P. macrocarpa extract using subCO2 soxhlet method was higher than the conventional sonication method and lower than the solvent extraction method. Overall, subCO2 soxhlet extraction of P. macrocarpa represents a promising method to produce organic solvent free and highly a-glucosidase inhibitory compounds containing extracts.
format	Article
author	Easmin, Sabina Sarker, Md. Zaidul Islam Ghafoor, Kashif Ferdosh, Sahena Jaffri, J. M. Akanda, Md. Jahurul Haque Al-Juhaimi, Fahad Y. Bostanudin, M. Fauzi Khatib, Alfi
author_facet	Easmin, Sabina Sarker, Md. Zaidul Islam Ghafoor, Kashif Ferdosh, Sahena Jaffri, J. M. Akanda, Md. Jahurul Haque Al-Juhaimi, Fahad Y. Bostanudin, M. Fauzi Khatib, Alfi
author_sort	Easmin, Sabina
title	Extraction of α-glucosidase inhibitory compounds from Phaleria macrocarpa fruit flesh using solvent, sonication, and subcritical carbon dioxide soxhlet methods
title_short	Extraction of α-glucosidase inhibitory compounds from Phaleria macrocarpa fruit flesh using solvent, sonication, and subcritical carbon dioxide soxhlet methods
title_full	Extraction of α-glucosidase inhibitory compounds from Phaleria macrocarpa fruit flesh using solvent, sonication, and subcritical carbon dioxide soxhlet methods
title_fullStr	Extraction of α-glucosidase inhibitory compounds from Phaleria macrocarpa fruit flesh using solvent, sonication, and subcritical carbon dioxide soxhlet methods
title_full_unstemmed	Extraction of α-glucosidase inhibitory compounds from Phaleria macrocarpa fruit flesh using solvent, sonication, and subcritical carbon dioxide soxhlet methods
title_sort	extraction of α-glucosidase inhibitory compounds from phaleria macrocarpa fruit flesh using solvent, sonication, and subcritical carbon dioxide soxhlet methods
publisher	Wiley-Blackwell Publishing Ltd
publishDate	2017
url	http://irep.iium.edu.my/59137/ http://irep.iium.edu.my/59137/ http://irep.iium.edu.my/59137/ http://irep.iium.edu.my/59137/1/easmin2017.pdf http://irep.iium.edu.my/59137/7/Extraction%20of%20a-glucosidase%20inhibitory%20compounds%20from.pdf
first_indexed	2023-09-18T21:23:44Z
last_indexed	2023-09-18T21:23:44Z
_version_	1777412052594196480

Extraction of α-glucosidase inhibitory compounds from Phaleria macrocarpa fruit flesh using solvent, sonication, and subcritical carbon dioxide soxhlet methods

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